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However, previous analyses have shown that the indirect estimation by PGW resulted in roughly similar outcomes compared to other indirect estimation techniques [30, 31, 48], so we are confident that our results are broadly reliable

Smoking has therefore led to adverse and extensive health effects through both passive and active means

This is a massive benefit to him

However, numerous experimental investigations have demonstrated that several substances, such as heavy metals, ionizing radiation, pesticides, dust and fibers, household coal, arsenic, asbestos, and polycyclic aromatic hydrocarbons, can cause cellular and molecular changes that can facilitate the development of cancer [54]

Smokers demonstrate a significantly elevated mortality risk compared to nonsmokers 5